Alert



acetaminophen (injection)

Pronunciation: a SEET a MIN oh FEN

Brand: Ofirmev

What is the most important information I should know about acetaminophen injection?

You should not use this medicine if you have severe liver disease.

Do not use more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

Be very careful when measuring your dose.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. Stop using this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

What is acetaminophen injection?

Acetaminophen injection is used to treat pain and to reduce fever in adults and children at least 2 years old.

Acetaminophen injection is sometimes given with opioid pain medication to treat moderate to severe pain in adults and children at least 2 years old.

Acetaminophen injection may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using acetaminophen injection?

You should not use this medicine if you are allergic to acetaminophen, or if you have severe liver disease.

Tell your doctor if you have ever had:

  • liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;
  • kidney disease; or
  • if you are malnourished.

Tell your doctor if you are pregnant or breastfeeding.

This medicine may affect fertility (your ability to have children), whether you are a man or a woman.

How is acetaminophen injection given?

Acetaminophen is given as an infusion into a vein, usually once every 4 to 6 hours. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Be very careful when measuring your dose. This medicine contains 10 milligrams (mg) of acetaminophen in each milliliter (mL) of the solution. If your dose is 1000 mg, for example, you would use only 100 mL of solution.

If you are using an infusion pump, take care to properly program the machine to deliver the correct amount of medicine for your dose.

Tell your doctor if you have any changes in weight while using this medicine. Lower doses are used in people who weigh less than 110 pounds (50 kilograms).

Do not use more of this medicine than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Store at room temperature away from heat and moisture. Do not refrigerate or freeze.

You must use the medicine within 6 hours after opening a vial.

What happens if I miss a dose?

Since acetaminophen is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose. Do not use two doses at one time.

Do not use acetaminophen injection more often than every 4 hours.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can damage your liver or cause death.

Early signs of acetaminophen overdose include loss of appetite, nausea, vomiting, sweating, or weakness. Later symptoms may include upper stomach pain, dark urine, and yellowing of your skin or eyes.

Overdose symptoms may also include hunger with irritability, fast heart rate, tremors, feeling jittery, trouble concentrating, easy bruising, unusual bleeding, or purple or red pinpoint spots under your skin.

What should I avoid while using acetaminophen injection?

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen (sometimes abbreviated as APAP). Using too much acetaminophen can lead to a fatal overdose.

Avoid drinking alcohol. It may increase your risk of liver damage.

What are the possible side effects of acetaminophen injection?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop using this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using acetaminophen and call your doctor at once if you have:

  • chest pain, trouble breathing; or
  • liver problems --nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • breathing problems;
  • nausea, vomiting;
  • constipation;
  • feeling agitated;
  • itching;
  • headache; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect acetaminophen injection?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect acetaminophen, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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